Scientist II - LNP Formulation

Scientist II – LNP FormulationLocation: San Diego, CA (Onsite; no relocation)

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Position SummarySeeking a motivated, detail-oriented Scientist II to join the Formulation team.Focus on the formulation, synthesis, and optimization of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery.Work closely with senior scientists to support in vitro and in vivo studies and advance non-viral delivery platforms.
Key ResponsibilitiesFormulate and optimize LNPs and targeted LNPs (tLNPs) encapsulating mRNA, siRNA, or DNA.Execute Design of Experiments (DoE) screening campaigns to identify optimal LNP compositions and processing parameters.Characterize LNPs using Dynamic Light Scattering (DLS), zeta potential, and RiboGreen assays.Support early-stage formulation development, cryoprotection, scale-up, and stability studies.Collaborate with cross-functional teams to fulfill formulation requests.Maintain detailed laboratory records documenting formulation activities and experimental results.Analyze, interpret, and present experimental data to the formulation team.Support routine laboratory operations, including inventory tracking, supply ordering, buffer preparation, and autoclaving.
Required QualificationsEducation and industry experience:Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline, with 5 years of biopharma industry experience; ORMaster's degree in a related discipline, with 2 years of industry experience.Minimum 2 years of hands-on laboratory experience in LNP formulation and nucleic acid encapsulation.Experience working with mRNA, siRNA, or DNA.Proficiency in LNP characterization techniques, including:Dynamic Light Scattering (DLS)Zeta potentialRiboGreen assaysHigh proficiency in Microsoft Excel.Strong attention to detail and ability to generate reproducible experimental data.Excellent organizational, communication, and teamwork skills.Ability to work effectively in a fast-paced laboratory environment.
Preferred QualificationsExperience preparing targeted LNPs using:Monoclonal antibodies (mAbs)Fab fragmentsSingle-chain variable fragments (scFv)VHH antibody fragmentsExperience with immune cell delivery. xzbcwsv Familiarity with statistical and data analysis software, such as JMP or GraphPad Prism.
Technical SkillsLipid Nanoparticle (LNP) Formulation and DevelopmentTargeted Lipid Nanoparticles (tLNPs)Nucleic Acid Encapsulation and DeliverymRNA, siRNA, and DNA DeliveryLNP Characterization and OptimizationDynamic Light Scattering (DLS)Zeta Potential AnalysisRiboGreen Assays and Encapsulation EfficiencyDesign of Experiments (DoE)Experimental Design and Data AnalysisFormulation Stability StudiesCryoprotection and Scale-UpIn Vitro and In Vivo Formulation SupportMicrosoft ExcelJMP / GraphPad PrismLaboratory Documentation and RecordkeepingBuffer Preparation and Inventory ManagementCross-Functional Collaboration